In the 1800s, bitters were synonymous with a most unlikely industry: medicine. A resurgence in craft cocktailing movement have thrown this once-obscure ingredient back in the spotlight. And now that dozens of brands and bartenders are creating their own versions of the aromatic additives—flavored with everything from roots, barks, herbs, fruits and spices—they’re becoming harder to ignore. Add these five bottles of bitters to your home bar arsenal. Your drinks will never be wanting again.