Translation: There are those who lose this battle - don't get on thone or find out very soon this is not job for them. And than there are winners - those who get on throne, or maybe not, but of natural cause, while assured this would really be a job for them. In short, the only difference is determination and not get yourself killed.
All the fandom is like: "Oh, wouldn't it be perfect if two greatest sultanas of all time met?" And I think that would probably ended up with Hürrem kicking her great-great-granson Ahmed's arse for dismissing the miniaturists and losing all tha battles. Not very glorious.