Indomethacin is a non-steroidal anti-inflammatory drug that inhibits prostaglandin synthesis to stop premature contraction. Nifedipine, a calcium channel blocker, stimulates smooth muscle relaxation, reducing the tone of myometrium and opposing contraction. Magnesium sulfate prevents premature contractions during pre-eclampsia it can reduce blood pressure levels and prevent convulsions or seizures. The terbutaune, a β2-adrenergic receptor agonist, by directly suppressing premature labor.